A New Drug for Alzheimer's Disease
Clinical evaluation of BMS-984923 metabolism.
This project is exploring a new medication called BMS-984923 that aims to protect brain connections in people with Alzheimer's disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Allyx Therapeutics INC. NIH-funded |
| Lab location | 1 site (New Haven, UNITED STATES) |
| Project ID | NIH-11195550 on NIH RePORTER |
What this research studies
Alzheimer's disease causes memory loss by damaging the connections between brain cells, called synapses. This new medication, BMS-984923, is designed to stop this damage by targeting a specific protein pathway in the brain. Early laboratory and animal studies showed that this drug helped restore brain connections, improve brain activity, and bring memory performance back to normal. We are now conducting initial human studies to understand how this drug works in people and confirm its safety.
Who could benefit from this research
Good fit: Patients with Alzheimer's disease who meet specific criteria for early-stage clinical trials may be ideal candidates for future participation.
Not a fit: Patients seeking immediate therapeutic benefit may not find it in these early-stage studies, which primarily focus on safety and how the drug behaves in the body.
Why it matters
Potential benefit: If successful, this medication could slow or stop the progression of Alzheimer's disease by protecting brain connections, potentially improving memory and cognitive function.
How similar studies have performed: Previous laboratory and animal studies have shown promising results for this drug and its approach in protecting brain connections related to Alzheimer's disease.
Where this research is happening
New Haven, UNITED STATES
- Allyx Therapeutics INC. — New Haven, United States (Active)
Researchers
- Principal investigator: Siegert, Timothy R — Allyx Therapeutics INC.
- Study coordinator: Siegert, Timothy R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.