A new diagnostic test for tuberculosis in HIV-infected children
Multiplexed Antigen-Specific Antibody Fc Profiling on a Chip for Point-of-Care Diagnosis of TB in HIV-infected Children
This study is working on a new, easy-to-use test for tuberculosis in children, especially those with HIV, that doesn't require them to cough up samples, making it simpler to diagnose and treat TB in young kids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10834976 on NIH RePORTER |
What this research studies
This research focuses on developing a cost-effective diagnostic test for tuberculosis (TB) specifically designed for children, particularly those infected with HIV. The approach utilizes a novel biomarker-based method that analyzes non-sputum samples, making it easier to diagnose TB in young children who often cannot provide sputum samples. By examining the glycosylation patterns of antibodies specific to TB, the researchers aim to differentiate between active TB disease and latent TB infection, which has been a significant challenge in pediatric care. The goal is to create a point-of-care test that can be used in resource-limited settings, ultimately improving TB treatment and reducing mortality rates among affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under the age of 5 who are either infected with HIV or are HIV-exposed but uninfected.
Not a fit: Patients who are older than 21 years or those without any risk factors for TB or HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a reliable and accessible diagnostic tool that significantly reduces TB-related deaths in HIV-infected children.
How similar studies have performed: While there have been challenges in developing effective pediatric TB diagnostics, recent advancements in antibody glycosylation analysis show promise, indicating that this approach could lead to successful outcomes.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Bryson, Bryan David — Massachusetts General Hospital
- Study coordinator: Bryson, Bryan David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.