A new device to study and test treatments for pulmonary arterial hypertension.
PAH-on-a-chip: a novel disease-on-a-device model for studying the pathobiology of and screening drugs for pulmonary arterial hypertension
This study is creating a special device that simulates the conditions of pulmonary arterial hypertension (PAH) using human cells, so researchers can better understand the disease and find new treatments that might help patients like you.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medluidics LLC NIH-funded |
| Lab location | 1 site (Elk Grove, United States) |
| Project ID | NIH-10851877 on NIH RePORTER |
What this research studies
This research focuses on developing a microfluidic device that mimics the conditions of pulmonary arterial hypertension (PAH) by incorporating human pulmonary arterial cells. The device aims to provide a more accurate model for understanding the disease and testing potential treatments, overcoming the limitations of traditional animal and cellular models. By using this innovative approach, researchers hope to gain insights into the factors contributing to PAH and the sex-disparity observed in its prevalence. Patients may benefit from more effective therapies developed through this advanced model.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension, particularly those affected by the disease's unique characteristics.
Not a fit: Patients with other forms of pulmonary hypertension or those without a diagnosis of pulmonary arterial hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective treatments for pulmonary arterial hypertension.
How similar studies have performed: While similar organ-on-a-chip technologies have shown promise in other diseases, this specific application for pulmonary arterial hypertension is novel and untested.
Where this research is happening
Elk Grove, United States
- Medluidics LLC — Elk Grove, United States (Active)
Researchers
- Principal investigator: Ahsan, Fakhrul — Medluidics LLC
- Study coordinator: Ahsan, Fakhrul
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.