A New Device for Precise Delivery of Addiction Treatments
Official title: Oscillated Insertion Tool for Minimally Invasive, Low-Damage, Accurate Placement of Delivery Cannula to Improve Efficacy for DREADDS Therapy in Alcohol Addiction Treatment
Funded at Actuated Medical, INC. · NIH-11093475 · Data updated 2026-11-12
This project is developing a special device to accurately deliver new gene-based treatments for alcohol addiction.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Actuated Medical, INC. NIH-funded |
| Lab location | 1 site (Bellefonte, United States) |
| Project start | September 1, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $1,379,360 |
| NIH project number | 5R44AA030512-03 |
| Project ID | NIH-11093475 on NIH RePORTER |
Who could benefit from this research
✓Could help
This work is foundational for future treatments, so patients with alcohol addiction who might be candidates for advanced gene therapies could eventually benefit.
✕Less likely to help
Patients whose addiction is not related to the brain regions targeted by these specific gene therapies, or who are not candidates for such invasive procedures, may not directly benefit from this particular device.
What this research studies
We are working on an advanced device called the Oscillated Syringe for Intracranial Injections (OSII) system. This device is designed to place tiny tubes, called cannulas, very gently and precisely into the brain. The goal is to improve how drugs and gene therapies, like those using adeno-associated viruses (AAVs), are delivered for conditions such as alcohol addiction. By making delivery more accurate and less damaging, we hope these promising new treatments will work better for patients.
Why it matters
Potential benefit: If successful, this device could make advanced gene therapies for alcohol addiction more effective and safer by ensuring precise delivery to the brain.
How similar studies have gone: Current methods for delivering gene therapies to the brain have limitations in precision, and this project aims to overcome those challenges with a novel device.
Where this research is happening
-
Actuated Medical, INC.
Bellefonte, United States Active
Researchers
- Principal investigator: Bagwell, Roger Brooks — Actuated Medical, INC.
- Study coordinator: Bagwell, Roger Brooks
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.