A new dental material to help regenerate damaged tooth structures
Official title: RegendoGEL for guided pulp and dentin regeneration
Funded at Regendodent, INC. · NIH-10932485 · Data updated 2026-11-12
This study is testing a new dental material called RegendoGEL that helps heal damaged teeth by using natural proteins, aiming to make dental treatments like root canals more effective and comfortable for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Regendodent, INC. NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $398,785 |
| NIH project number | 1R41DE033326-01A1 |
| Project ID | NIH-10932485 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with dental pulp damage due to trauma or decay who require vital pulp therapy or root canal treatment.
✕Less likely to help
Patients with fully necrotic pulp or those who do not require pulp regeneration may not benefit from this research.
What this research studies
This research focuses on developing RegendoGEL, a novel dental material designed to stimulate the regeneration of dental pulp and dentin that have been damaged due to decay or trauma. The approach involves using natural tooth-derived proteins to promote healing and repair in a controlled manner, similar to existing dental therapies. The material will be tested in clinical settings for its effectiveness in vital pulp therapy and root canal treatments, with the goal of replacing traditional nondegradable materials. Patients may benefit from improved dental repair outcomes and reduced inflammation during the healing process.
Why it matters
Potential benefit: If successful, this research could lead to more effective and less invasive treatments for dental pulp and dentin damage.
How similar studies have gone: Previous research has shown promise in using similar biological materials for dental regeneration, indicating potential for success with this novel approach.
Where this research is happening
-
Regendodent, INC.
Ann Arbor, United States Active
Researchers
- Principal investigator: Crane, Michael — Regendodent, INC.
- Study coordinator: Crane, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.