A new compact device for detecting low-abundance protein biomarkers at the point-of-care.
SEMI-SIMOA: A Chip-scale Flow-based Single-Molecule Assay at the Point-of-Care using Semiconductor Technology
['FUNDING_R21'] · UNIVERSITY OF CALIFORNIA BERKELEY · NIH-11132821
This study is working on a small, easy-to-use device that can quickly and accurately detect important proteins related to neurological conditions, helping patients get faster diagnoses and treatment right where they are, without needing complicated lab equipment.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA BERKELEY (nih funded) |
| Locations | 1 site (BERKELEY, UNITED STATES) |
| Trial ID | NIH-11132821 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a compact single-molecule assay (SIMOA) system that can detect low-abundance protein biomarkers, such as those related to neurological conditions, using a semiconductor chip. The innovative design integrates microfluidics and electronics into a small device, allowing for easy use outside of specialized laboratories. Patients can benefit from this technology as it enables rapid and accurate diagnostics directly at the point-of-care, potentially leading to quicker treatment decisions. The system is designed to be user-friendly, allowing results to be viewed on personal devices without the need for bulky equipment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions or those requiring biomarker testing for diagnosis.
Not a fit: Patients with conditions that do not involve low-abundance protein biomarkers may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide patients with faster and more accessible diagnostic testing for various conditions.
How similar studies have performed: Other research has shown success with similar single-molecule assay technologies, indicating a promising approach for point-of-care diagnostics.
Where this research is happening
BERKELEY, UNITED STATES
- UNIVERSITY OF CALIFORNIA BERKELEY — BERKELEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHIEN, JUN-CHAU — UNIVERSITY OF CALIFORNIA BERKELEY
- Study coordinator: CHIEN, JUN-CHAU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.