A new blood test for diagnosing Alzheimer's Disease
Official title: Whole blood filter paper assay for Alzheimers Disease
Funded at Biospyder Technologies, INC. · NIH-11128974 · Data updated 2026-11-12
This study is working on a simple blood test that could help doctors diagnose Alzheimer's Disease and other types of dementia earlier and more accurately, making it easier for people who are having memory issues to get the answers they need.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Biospyder Technologies, INC. NIH-funded |
| Lab location | 1 site (Carlsbad, United States) |
| Project start | August 1, 2019 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $115,472 |
| NIH project number | 3R44AG065039-03S1 |
| Project ID | NIH-11128974 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing mild cognitive impairment or those at risk for Alzheimer's Disease.
✕Less likely to help
Patients with established Alzheimer's Disease who are already receiving treatment may not benefit from this research.
What this research studies
This research focuses on developing a blood test that can help diagnose Alzheimer's Disease and potentially other forms of dementia. The test uses a small sample of blood collected via a finger-stick, which is then placed on filter paper and analyzed using advanced gene expression technology. The goal is to create a reliable diagnostic tool that can identify Alzheimer's with high accuracy, addressing a significant need for early and definitive diagnosis. This approach aims to reduce the uncertainty and delay in diagnosing patients who may be experiencing mild cognitive impairment.
Why it matters
Potential benefit: If successful, this research could provide a quick and accurate method for diagnosing Alzheimer's Disease, allowing for earlier intervention and better patient management.
How similar studies have gone: Previous research has shown promising results with similar blood-based diagnostic approaches for Alzheimer's Disease, indicating potential for success in this area.
Where this research is happening
-
Biospyder Technologies, INC.
Carlsbad, United States Active
Researchers
- Principal investigator: Seligmann, Bruce E. — Biospyder Technologies, INC.
- Study coordinator: Seligmann, Bruce E.
Related research
Other NIH-funded projects on the same topics.
-
Understanding how brain activity changes may drive Alzheimer’s disease progression in a mouse model
Researchers are testing how changes in brain signals and protein cleanup processes affect the development of Alzheimer’s disease in mice.
-
Thiamine-boosting therapy for Alzheimer’s: understanding how benfotiamine may reduce harmful AGE in DP patients
A medication-based approach using high-dose vitamin B1 (benfotiamine) is studied to help people with Alzheimer's by reducing harmful sugar-related molecules.
-
Non-invasive tears biomarker for early Alzheimer's in LMICs
A low-cost, tear-based biomarker approach aims to detect early Alzheimer’s disease in older adults in Peru and similar settings.
-
Cognitive SuperAging: Exploring why some octogenarians stay sharp in memory
This NIH grant studies why a small group of people aged 80+ keep memory skills as good as much younger people, hoping to understand how to protect memory as we age.
-
CLU's role in Alzheimer's disease pathogenesis
Researchers are studying how the CLU gene may drive brain changes in Alzheimer's disease and how targeting CLU could lead to safer treatments.
-
Turning APOE4 into protective APOE2 or APOE3Christchurch to help with Alzheimer’s
A patient-facing explanation of a treatment idea that aims to change a genetic risk factor for Alzheimer's disease in the brain.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.