A new biomarker to predict how Parkinson's disease progresses
Superoxide-sensitive radiotracer as a predictive biomarker of Parkinson's disease progression
This study is looking at how certain signals in your cells might help predict the progression of Parkinson's disease, focusing on how stress in your mitochondria could show early signs of symptoms, and it’s for people who want to understand more about their condition and how it might change over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10747895 on NIH RePORTER |
What this research studies
This research investigates how mitochondrial stress signals, particularly superoxide, can serve as predictive biomarkers for the progression of Parkinson's disease. By examining the relationship between genetic and environmental factors and mitochondrial dysfunction, the study aims to identify early indicators of neurodegeneration. Patients will be monitored for oxidative stress levels, which may signal the onset of Parkinson's symptoms. The approach involves analyzing blood-brain barrier permeability and the role of immune responses in the aging brain.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Parkinson's disease due to genetic or environmental factors.
Not a fit: Patients who are already diagnosed with advanced Parkinson's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and better management strategies for patients with Parkinson's disease.
How similar studies have performed: Previous research has shown promise in using mitochondrial stress signals as biomarkers in neurodegenerative diseases, indicating a potential for success in this approach.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Mcmanus, Meagan Joy — Children's Hosp of Philadelphia
- Study coordinator: Mcmanus, Meagan Joy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.