A new, better way to make rAAV gene therapy vectors
Official title: A novel strategy for the next generation rAAV gene therapy and vaccine vector production
Funded at Neovaxsyn, INC. · NIH-11315811 · Data updated 2026-11-12
Aims to create a better, higher-quality rAAV production method to support future gene therapies and vaccines.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Neovaxsyn, INC. NIH-funded |
| Lab location | 1 site (Ames, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $300,000 |
| NIH project number | 1R43AI197694-01 |
| Project ID | NIH-11315811 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients who may eventually receive rAAV-based therapies or participate in related future trials could be impacted by this work.
✕Less likely to help
This project is early-stage and may not directly benefit patients in the near term.
What this research studies
This project focuses on making rAAV vectors safer and more effective by optimizing how they are produced and purified. Researchers will compare current production methods with a new OneBacmid system designed to work in mammalian cells, aiming for higher quality and yield. The work involves laboratory testing with cell cultures to refine the process before any potential human use. If successful, the method could streamline development of gene therapies and vaccines that rely on rAAV vectors.
Why it matters
Potential benefit: If successful, patients could benefit from more reliable and scalable rAAV-based gene therapies and vaccines.
How similar studies have gone: Previous methods have trade-offs between yield and quality; this project proposing a unified system is a novel approach.
Where this research is happening
-
Neovaxsyn, INC.
Ames, United States Active
Researchers
- Principal investigator: Raychaudhuri, Santanu — Neovaxsyn, INC.
- Study coordinator: Raychaudhuri, Santanu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.