NIH-funded research Sbir 2 grant

A new bandage that helps treat eczema by balancing skin bacteria

Official title: Controlled Release Eczema Bandage (CREB)

Funded at Cfd Research Corporation · NIH-10921604 · Data updated 2026-11-12

This study is testing a new type of bandage that uses a natural ingredient to help calm eczema flare-ups without harming your skin's good bacteria, aiming to offer a gentler treatment option for both kids and adults who struggle with atopic dermatitis.

More Eczema research and trials

Quick facts

Grant typeSbir 2 grant
Study typeNIH-funded research
Funding institutionCfd Research Corporation
NIH-funded
Lab location1 site (Huntsville, United States)
Project startAugust 1, 2021
Project endAugust 31, 2026
Funding year2024
Award (this year)$656,274
NIH project number2R44AT011486-02A1
Project IDNIH-10921604 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research include individuals of all ages suffering from atopic dermatitis, particularly those who experience frequent flare-ups.

Less likely to help

Patients with eczema who do not respond to topical treatments or have other underlying skin conditions may not benefit from this research.

What this research studies

This research focuses on developing a novel wet wrap therapy for atopic dermatitis, which is a common skin condition causing eczema. The therapy uses a natural compound that modulates the immune response to soothe eczema flare-ups while being gentle on the skin's beneficial bacteria. The compound is incorporated into cellulose-based fabrics, creating a controlled-release bandage that will be tested in mouse models before potential human application. The goal is to provide an effective treatment option that reduces reliance on steroid ointments for both children and adults.

Why it matters

Potential benefit: If successful, this research could provide a new standard treatment for eczema that minimizes the need for steroid medications.

How similar studies have gone: Similar approaches using microbiome-balancing therapies have shown promise in other dermatological conditions, suggesting potential success for this novel treatment.

Where this research is happening

  • Cfd Research Corporation
    Huntsville, United States
    Active

Researchers

  • Principal investigator: Singhal, Aj — Cfd Research Corporation
  • Study coordinator: Singhal, Aj

Related research

Other NIH-funded projects on the same topics.

  • Controlled-release eczema bandage

    A soft bandage that slowly releases a natural, microbiome-friendly compound to calm eczema flare-ups in children and adults.

    NIH research Cfd Research Corporation · Huntsville, United States · NIH-11195587

  • How exposure to heavy metals, nanoparticles, and emerging contaminants relates to allergic skin and systemic metal reactions

    This project will test whether adults with allergic contact dermatitis or systemic metal allergies have different levels of heavy metals, nanoparticles, and related blood and urine markers compared with healthy adults.

    Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Bologna and 1 other locations · NCT06529913

  • Digital mindfulness app for teens with eczema

    Teens with moderate to severe eczema try a digital mindfulness app to see if it helps control symptoms and improve quality of life.

    Recruiting at 2 sites Weill Medical College of Cornell University · New York, New York and 1 other locations · NCT07746427

  • Camoteskimab in adults with moderate-to-severe atopic dermatitis

    This trial tests different doses of camoteskimab versus placebo to see if it helps adults with moderate-to-severe atopic dermatitis who have not fully responded to standard treatments.

    Recruiting at 31 sites Phase 2 Apollo Therapeutics Ltd · Birmingham, Alabama and 84 other locations · NCT07599813

  • ARQ-234 single and multiple rising dose testing

    This will test different single and repeated doses of ARQ-234 to see if they are safe and how the drug behaves in healthy adults and adults with moderate-to-severe atopic dermatitis.

    Recruiting at 7 sites Phase 1 Arcutis Biotherapeutics, Inc. · Miami, Florida and 6 other locations · NCT07453602

  • Low-sodium diet and salt tablets to see if eczema improves

    This study tests whether a low-sodium diet can lessen eczema symptoms in adults with atopic dermatitis, using a cross-over design with sodium tablets and placebo to see if salt intake changes skin sodium and severity.

    Recruiting at 2 sites Phase 4 University of California, San Francisco · San Francisco, California and 1 other locations · NCT07447063

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.