A new assay to measure kinase activity for cancer treatment
A new multi-pathway kinase activity assay applied to compound library screening in cancer biology
This study is working on a new way to quickly check how certain proteins that help cancer grow are working, using advanced technology, to find better treatments for cancer by testing in both flat and 3D cell setups that look more like real tumors.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10914904 on NIH RePORTER |
What this research studies
This research focuses on developing a high-throughput assay to measure the activity of protein kinases, which are crucial in cancer biology. By using advanced technologies like Tandem Mass Tag (TMT) reagents and mass spectrometry, the study aims to create a more efficient way to screen for potential cancer drugs. The approach includes testing kinase activity in both traditional 2D cell cultures and more complex 3D cell cultures, which better mimic actual tumor environments. This could lead to the discovery of new therapeutic targets and improve drug screening processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with various types of cancer who may benefit from new targeted therapies.
Not a fit: Patients with cancers that are not driven by kinase signaling pathways may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments by identifying new drug targets and improving the drug discovery process.
How similar studies have performed: Other research has shown success in using high-throughput assays for drug discovery, indicating that this approach has potential.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Zhang, Tian — University of Virginia
- Study coordinator: Zhang, Tian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.