A new approach to understanding how cancer cells evade the immune system.
A Novel Immune Tolerization Strategy for Investigating the Trade-offs between Oncogene Pathogenicity and Immunogenicity.
['FUNDING_FELLOWSHIP'] · BAYLOR COLLEGE OF MEDICINE · NIH-11071477
This study is looking at how cancer cells hide from the immune system while they grow, and it’s testing a new method to help the immune system spot these sneaky cells better, which could lead to new ways to catch cancer early and improve treatments.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11071477 on ClinicalTrials.gov |
What this research studies
This research investigates how cancer cells can avoid detection by the immune system while still growing. It uses a novel technique called RECON to transform certain cancer-related proteins into self-antigens, which helps the immune system recognize them. By studying these changes, researchers aim to understand the balance between cancer growth and immune evasion. This could lead to new insights into early cancer development and potential treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with early-stage cancers or those at high risk for developing cancer.
Not a fit: Patients with advanced-stage cancers or those whose cancers are not driven by oncogene activation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting early-stage cancer cells before they fully develop.
How similar studies have performed: Other research has shown promise in using immune tolerization strategies, suggesting that this approach could be effective.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HOFFMAN, DANE KRISTIAN — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: HOFFMAN, DANE KRISTIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cancer antigens, cancer cell, cancer evasion, Cancer Genes, cancer immune escape