A new approach to understanding how cancer cells evade the immune system.
Official title: A Novel Immune Tolerization Strategy for Investigating the Trade-offs between Oncogene Pathogenicity and Immunogenicity.
Funded at Baylor College of Medicine · NIH-11071477 · Data updated 2026-11-12
This study is looking at how cancer cells hide from the immune system while they grow, and it’s testing a new method to help the immune system spot these sneaky cells better, which could lead to new ways to catch cancer early and improve treatments.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | April 21, 2025 |
| Project end | April 20, 2027 |
| Funding year | 2025 |
| Award (this year) | $49,538 |
| NIH project number | 1F31CA298561-01 |
| Project ID | NIH-11071477 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with early-stage cancers or those at high risk for developing cancer.
✕Less likely to help
Patients with advanced-stage cancers or those whose cancers are not driven by oncogene activation may not benefit from this research.
What this research studies
This research investigates how cancer cells can avoid detection by the immune system while still growing. It uses a novel technique called RECON to transform certain cancer-related proteins into self-antigens, which helps the immune system recognize them. By studying these changes, researchers aim to understand the balance between cancer growth and immune evasion. This could lead to new insights into early cancer development and potential treatments.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting early-stage cancer cells before they fully develop.
How similar studies have gone: Other research has shown promise in using immune tolerization strategies, suggesting that this approach could be effective.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Hoffman, Dane Kristian — Baylor College of Medicine
- Study coordinator: Hoffman, Dane Kristian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.