A new approach to prevent low blood sugar and insulin resistance in diabetes
Official title: A Novel Nitrosylase Prevents Hypoglycemia and Mediates Insulin Resistance
Funded at Case Western Reserve University · NIH-10997381 · Data updated 2026-11-12
This study is looking at how certain enzymes influence insulin signaling in the body, especially in relation to insulin resistance and blood sugar levels, to find new ways to help people with diabetes manage their condition better, particularly as they age or if they are dealing with obesity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $506,342 |
| NIH project number | 5R01DK137973-02 |
| Project ID | NIH-10997381 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with type 2 diabetes, particularly those experiencing insulin resistance or related complications.
✕Less likely to help
Patients who do not have type 2 diabetes or those with other forms of diabetes may not receive benefits from this research.
What this research studies
This research investigates a novel mechanism that regulates insulin signaling in the body, particularly focusing on how certain enzymes affect insulin resistance and blood sugar levels. By studying the role of S-nitrosylation in insulin receptors, the research aims to identify new therapeutic targets that could improve insulin sensitivity and prevent hypoglycemia. The approach involves examining how these mechanisms change with obesity and aging, which are significant factors in type 2 diabetes. Patients may benefit from insights that could lead to new treatments for managing their diabetes effectively.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve insulin sensitivity and help manage blood sugar levels in patients with type 2 diabetes.
How similar studies have gone: Other research has shown promise in targeting insulin signaling pathways, but this specific approach focusing on S-nitrosylation is relatively novel.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Stamler, Jonathan S. — Case Western Reserve University
- Study coordinator: Stamler, Jonathan S.
Related research
Other NIH-funded projects on the same topics.
-
A protein that controls insulin signaling and prevents low blood sugar
This work focuses on a protein called SCAN that may drive insulin resistance in people with type 2 diabetes and aims to restore normal insulin signaling.
-
Technological and Educational Approaches to Restore Hypoglycemia Awareness in Type 1 Diabetes
A two-arm study in adults with type 1 diabetes tests whether high-tech glucose control plus education or targeted training can help people regain awareness of low blood sugar.
-
Techniques for restoring awareness of low blood sugar in adults with type 1 diabetes
A randomized trial compares different approaches to help adults with type 1 diabetes recognize when their blood sugar is dipping so they can act quickly.
-
Treating impaired hypoglycemia awareness in type 1 diabetes with targeted education and technology
This study tests two treatment approaches to help adults with type 1 diabetes who often don’t realize their blood sugar is getting too low, using a mix of technology and education in two large groups.
-
Helping people with type 1 diabetes regain awareness of dangerous lows
A UK study tests two different approaches to help adults with type 1 diabetes recognize and respond to low blood sugar by comparing a high-tech insulin system with targeted education.
-
Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it
This study will look at adults with type 1 diabetes to see how their awareness of low blood sugar evolves over time and whether automated insulin delivery and high-intensity exercise can help restore that awareness.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.