A new approach to prevent low blood sugar and insulin resistance in diabetes
A Novel Nitrosylase Prevents Hypoglycemia and Mediates Insulin Resistance
This study is looking at how certain enzymes influence insulin signaling in the body, especially in relation to insulin resistance and blood sugar levels, to find new ways to help people with diabetes manage their condition better, particularly as they age or if they are dealing with obesity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10997381 on NIH RePORTER |
What this research studies
This research investigates a novel mechanism that regulates insulin signaling in the body, particularly focusing on how certain enzymes affect insulin resistance and blood sugar levels. By studying the role of S-nitrosylation in insulin receptors, the research aims to identify new therapeutic targets that could improve insulin sensitivity and prevent hypoglycemia. The approach involves examining how these mechanisms change with obesity and aging, which are significant factors in type 2 diabetes. Patients may benefit from insights that could lead to new treatments for managing their diabetes effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with type 2 diabetes, particularly those experiencing insulin resistance or related complications.
Not a fit: Patients who do not have type 2 diabetes or those with other forms of diabetes may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve insulin sensitivity and help manage blood sugar levels in patients with type 2 diabetes.
How similar studies have performed: Other research has shown promise in targeting insulin signaling pathways, but this specific approach focusing on S-nitrosylation is relatively novel.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Stamler, Jonathan S. — Case Western Reserve University
- Study coordinator: Stamler, Jonathan S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.