A new approach to prepare patients for hematopoietic stem cell transplants without damaging their DNA.
Targeted non-genotoxic hematopoietic stem cell transplant conditioning approach
['FUNDING_CAREER'] · EMORY UNIVERSITY · NIH-10674774
This study is looking for a safer way to prepare patients for stem cell transplants by using new techniques that avoid harmful chemotherapy or radiation, so that people can have a better experience and fewer long-term health issues.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-10674774 on ClinicalTrials.gov |
What this research studies
This research focuses on improving the conditioning process for hematopoietic stem cell transplants (HSCT) by developing a non-genotoxic regimen. Traditional methods often use harmful chemotherapy or radiation, which can lead to serious complications. The study aims to target specific cells in the blood system using innovative techniques, such as immunotoxins and CAR-T cells, to enhance the safety and effectiveness of the transplant process. Patients may benefit from a safer treatment option that minimizes long-term health risks.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients requiring hematopoietic stem cell transplants for blood disorders.
Not a fit: Patients who do not require a stem cell transplant or have conditions unrelated to the lymphohematopoietic system may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a safer conditioning method for patients undergoing hematopoietic stem cell transplants, reducing the risk of complications.
How similar studies have performed: While the approach of targeting specific receptors in stem cells is innovative, similar strategies have shown promise in other areas of hematology, suggesting potential for success.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHANDRAKASAN, SHANMUGANATHAN — EMORY UNIVERSITY
- Study coordinator: CHANDRAKASAN, SHANMUGANATHAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.