A new approach to bone marrow transplantation for sickle cell disease using targeted radiation.
Official title: A Novel Bone Marrow Transplantation Approach for Sickle Cell Disease Using Targeted Marrow Irradiation
Funded at Beckman Research Institute/city of Hope · NIH-10869998 · Data updated 2026-11-12
This study is exploring a new way to treat sickle cell disease using a special bone marrow transplant technique that carefully targets radiation to help the transplant work better while protecting important organs, and it's designed for patients looking for improved treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $343,450 |
| NIH project number | 5R01HL164895-02 |
| Project ID | NIH-10869998 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with sickle cell disease who may benefit from bone marrow transplantation.
✕Less likely to help
Patients who do not have sickle cell disease or those who are not eligible for bone marrow transplantation may not receive any benefit from this research.
What this research studies
This research investigates a novel method for treating sickle cell disease (SCD) through a specialized bone marrow transplantation technique that uses targeted marrow irradiation. The approach aims to minimize damage to vital organs while enhancing the effectiveness of the transplant. By utilizing advanced imaging technology, the researchers can precisely deliver radiation to the bone marrow, potentially improving patient outcomes and reducing the risk of complications. The study will involve preclinical models to better understand how this method can increase donor cell acceptance and improve treatment success.
Why it matters
Potential benefit: If successful, this research could provide a safer and more effective curative treatment option for patients with sickle cell disease.
How similar studies have gone: Other research has shown promise with similar targeted irradiation approaches, indicating potential for success in this novel application.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Hui, Susanta K — Beckman Research Institute/city of Hope
- Study coordinator: Hui, Susanta K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.