A new antibiotic-loaded envelope to prevent infections in heart devices
Official title: ARRAY: A novel polymeric mesh for prophylactic antibiotic protection of cardiac implantable electronic devices
Funded at 21medtech LLC · NIH-10764828 · Data updated 2026-11-12
This study is testing a new type of mesh that helps prevent infections after heart devices are implanted by slowly releasing antibiotics, making it safer for patients who need these devices.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | 21medtech LLC NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $992,480 |
| NIH project number | 5R44HL167315-02 |
| Project ID | NIH-10764828 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who are scheduled to receive cardiovascular implantable electronic devices.
✕Less likely to help
Patients who do not require a cardiovascular implantable electronic device or those with existing severe infections may not benefit from this research.
What this research studies
This research focuses on developing a novel polymeric mesh called the ARRAY envelope, designed to reduce the risk of infections associated with cardiovascular implantable electronic devices (CIEDs). The ARRAY envelope releases antibiotics locally after the device is implanted, aiming to provide longer-term protection against infections that can lead to severe health complications. The approach involves using a bioresorbable polymer that allows for controlled release of antibiotics over time, enhancing the safety and effectiveness of CIED procedures. The research has already shown promising results in laboratory settings, indicating that this method could significantly improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could greatly reduce the incidence of infections in patients receiving heart devices, leading to improved survival rates and quality of life.
How similar studies have gone: Previous research has shown success with similar antibiotic delivery methods in reducing infection rates, indicating that this approach has potential for effective application.
Where this research is happening
-
21medtech LLC
Durham, United States Active
Researchers
- Principal investigator: Yu, Jiayi — 21medtech LLC
- Study coordinator: Yu, Jiayi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.