A new animal-free, amino acid-based membrane to improve bone healing in facial surgery
Official title: Enhancing Dental and Craniomaxillofacial Surgery Outcomes with Cost-Effective and Scalable Animal-Free Amino Acid-Based Membranes for Guided Bone Regeneration
Funded at Matregenix · NIH-11460454 · Data updated 2026-11-12
A new, inexpensive, animal-free membrane called MatriNova may help bone growth in dental and facial surgeries by replacing traditional membranes.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Matregenix NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 1, 2025 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,119,000 |
| NIH project number | 5R44DE035026-02 |
| Project ID | NIH-11460454 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients needing bone regeneration in dental or craniofacial procedures who would receive barrier membranes as part of their treatment.
✕Less likely to help
Patients without craniofacial bone defects or those not needing barrier membranes may not benefit.
What this research studies
This project aims to improve guided bone regeneration for jaw and facial defects using an innovative, animal-free membrane made from amino acid-based polymers. The membrane is designed to be strong yet flexible, fitting cavity shapes without tearing or displacing, and it degrades into harmless amino acids. The research involves scaling up production and testing the material’s performance in bone healing, with a focus on safety and compatibility. If successful, it could reduce donor-site surgeries and lower treatment costs for patients needing facial bone regeneration.
Why it matters
Potential benefit: If successful, patients could benefit from better bone healing with fewer complications and lower treatment costs.
How similar studies have gone: Previous membranes have shown variable performance; this project aims to provide a robust, animal-free alternative with strong data in earlier preclinical work.
Where this research is happening
-
Matregenix
Boston, United States Active
Researchers
- Principal investigator: Soliman, Sherif — Matregenix
- Study coordinator: Soliman, Sherif
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.