A network for people at risk of psychosis
ProNET: Psychosis-Risk Outcomes Network
This project follows people at high risk for psychosis using brain scans, sensors, and symptom checks to help predict and prevent more severe illness.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11382684 on NIH RePORTER |
What this research studies
You would visit a participating clinic for detailed testing including MRI scans, EEG, genetic and blood/saliva samples, speech tasks, and smartphone-based monitoring. The project will follow about 1,040 people at clinical high risk across 26 international sites and compare them with 260 healthy volunteers over 24 months with repeated visits. Biomarkers will be collected at multiple timepoints to map how brain and behavior change and to link measurements to clinical outcomes. The team will also explore new EEG measures and real-time phone data to look for early warning signs and treatment-relevant trajectories.
Who could benefit from this research
Good fit: Ideal candidates are people identified as clinical high risk for psychosis—those with recent unusual thoughts, subtle psychotic symptoms, or a recent decline in social or occupational functioning.
Not a fit: People without signs of being at risk or those already diagnosed with a psychotic disorder are unlikely to be eligible or to gain direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could lead to earlier, more personalized ways to prevent or reduce psychosis in people at risk.
How similar studies have performed: Smaller studies of high-risk groups and multi-modal biomarkers have shown promising but inconsistent results, so this larger international effort is relatively novel.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Woods, Scott W — Yale University
- Study coordinator: Woods, Scott W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.