A more complete, inclusive map of the human genome
Human Pangenome Reference
['FUNDING_OTHER'] · WASHINGTON UNIVERSITY · NIH-11180273
Creating a fuller human DNA reference by adding genomes from people of diverse ancestries so researchers worldwide can use it.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11180273 on ClinicalTrials.gov |
What this research studies
The team is collecting high-quality DNA sequences from people across broad biogeographical ancestries to build a more complete human pangenome. They will produce haplotype-resolved genome assemblies, align these assemblies, and add gene annotations for each one so genetic differences are easier to find and compare. All core samples will be consented for open-access sharing and the project will develop file formats and software tools to help others work with the pangenome. The consortium will coordinate with the broader scientific community and gather feedback to address technical and ethical challenges and improve adoption.
Who could benefit from this research
Good fit: People willing to donate DNA and related health information are potential participants, with special interest in individuals from underrepresented ancestral backgrounds.
Not a fit: Individuals seeking immediate medical treatment or those unwilling to share genetic data publicly are unlikely to receive direct benefits from participation.
Why it matters
Potential benefit: If successful, this could help researchers identify genetic contributors to disease more accurately and make genetic tests and treatments more equitable across populations.
How similar studies have performed: Earlier efforts produced a draft human pangenome and useful tools, and this project builds on those successes to expand representation and usability.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, TING — WASHINGTON UNIVERSITY
- Study coordinator: WANG, TING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.