A model to predict how substances affect the placenta and fetus
A synergistic in vitro-in silico model of the placental barrier for predicting fetal exposure and toxicity of xenobiotic compounds
This study is exploring how the placenta works to protect the baby during pregnancy and how different substances, like medications, can affect the baby, using a special lab model to help improve drug safety for moms and their little ones.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cfd Research Corporation NIH-funded |
| Lab location | 1 site (Huntsville, United States) |
| Project ID | NIH-10847420 on NIH RePORTER |
What this research studies
This research investigates the placenta's role as a barrier between mother and fetus, focusing on how it transports various compounds. The team has developed a microfluidic model that mimics the placental barrier, allowing for the assessment of how different substances, including medications, can affect fetal exposure and toxicity. By integrating both in vitro (lab-based) and in silico (computer-based) approaches, the research aims to create a standardized tool for predicting maternal and fetal pharmacokinetics and toxicity. This could lead to better understanding and management of drug safety during pregnancy.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals, particularly those in their third trimester, who may be exposed to various medications.
Not a fit: Patients who are not pregnant or those in the early stages of pregnancy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance the safety of medications used during pregnancy by predicting their effects on the fetus.
How similar studies have performed: Other research has shown promise in using microfluidic models for studying placental transport, indicating a potential for success with this approach.
Where this research is happening
Huntsville, United States
- Cfd Research Corporation — Huntsville, United States (Active)
Researchers
- Principal investigator: German, Carrie — Cfd Research Corporation
- Study coordinator: German, Carrie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.