A method to predict severe COVID-19 in children with multiple respiratory infections
An Integrated Host-Microbe Gene Classifier to Predict SARS-CoV-2 and Severe Disease in Children with Respiratory Viral Coinfections
This study is looking at how to better understand and predict how serious COVID-19 can be in kids who also have other respiratory viruses, so doctors can make smarter treatment choices for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arkansas Children's Hospital Res Inst NIH-funded |
| Lab location | 1 site (Little Rock, United States) |
| Project ID | NIH-11095883 on NIH RePORTER |
What this research studies
This research investigates how to better understand and predict the severity of COVID-19 in children who may also be infected with other respiratory viruses. By analyzing genetic information from children with respiratory viral coinfections, the study aims to identify specific features and responses that contribute to more severe disease outcomes. The researchers will use advanced techniques like metagenomic next-generation sequencing to evaluate both viral and microbial contributions to illness. This approach could help clinicians make more informed treatment decisions for affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are experiencing respiratory infections, particularly those with suspected or confirmed COVID-19.
Not a fit: Patients who are adults or those without respiratory viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prediction and management of severe COVID-19 cases in children, potentially saving lives and reducing hospitalizations.
How similar studies have performed: Similar research approaches have shown promise in adult populations, but this specific application in pediatric patients is relatively novel.
Where this research is happening
Little Rock, United States
- Arkansas Children's Hospital Res Inst — Little Rock, United States (Active)
Researchers
- Principal investigator: Kennedy, Joshua — Arkansas Children's Hospital Res Inst
- Study coordinator: Kennedy, Joshua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.