A method to analyze proteins in individual cells
Highly sensitive proteomics method to probe cell heterogeneity at single cell resolution
This study is working on a new way to look at proteins in individual cells, which can help us understand how cells behave in conditions like brain development and cancer, ultimately giving us better insights into how diseases start and change over time.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-10693198 on NIH RePORTER |
What this research studies
This research focuses on developing a highly sensitive method to analyze proteins at the single-cell level, which is crucial for understanding cell diversity in conditions like neuron development and tumor evolution. By combining innovative chemical labeling techniques and advanced statistical models, the project aims to provide a clearer picture of how individual cells function and interact. This approach will allow researchers to quantify proteins in single mammalian cells, enhancing our understanding of cellular mechanisms and disease processes. Patients may benefit from insights gained into how diseases develop and progress at the cellular level.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to cell heterogeneity, such as certain cancers or neurodevelopmental disorders.
Not a fit: Patients with conditions that do not involve significant cell heterogeneity or those who are not undergoing treatment for related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding diseases and developing targeted therapies based on individual cell behavior.
How similar studies have performed: Other research has shown success in using single-cell proteomics to understand cellular mechanisms, indicating that this approach is promising and builds on established methodologies.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Gao, Yu — University of Illinois at Chicago
- Study coordinator: Gao, Yu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.