A hub analyzing molecular signals behind atrial fibrillation
Network and Systems Biology Scientific Core 3
Using genetic and molecular information from people with atrial fibrillation to pinpoint new ways to prevent and treat the condition.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11166598 on NIH RePORTER |
What this research studies
This core collects and processes large-scale molecular data—like RNA sequencing (bulk and single-nucleus), proteins, and metabolites—linked to atrial fibrillation. Lab-based functional test results from partner projects are combined with these datasets to map biological networks in the heart. The core team integrates and models the data to identify molecular drivers and potential drug targets. Findings will guide the other projects in the program as they move toward therapies and prevention strategies.
Who could benefit from this research
Good fit: Ideal candidates are people diagnosed with atrial fibrillation who can provide blood or heart tissue samples (for example, during clinical care or surgery) or agree to share existing genetic/molecular data for research.
Not a fit: People without atrial fibrillation or those needing immediate clinical treatment are unlikely to get direct, short-term benefits from this molecular research.
Why it matters
Potential benefit: If successful, this work could reveal new drug targets or preventive strategies that reduce AF episodes and lower stroke and heart-failure risk.
How similar studies have performed: Genetic and molecular studies have previously identified pathways linked to AF but translating those findings into new drugs has been slow, so this integrated systems approach is relatively novel and aims to bridge that gap.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Barnard, John — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Barnard, John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.