A genetic variant linked to obesity and diabetes
A human genetic variant ties defective hypothalamic development to obesity and diabetes
This study is looking at a specific genetic change that may cause early obesity and diabetes, using specially designed mice to learn how it affects the brain and metabolism, which could help us understand why some people struggle with weight and blood sugar issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11004657 on NIH RePORTER |
What this research studies
This research investigates a specific genetic mutation, OtpQ153R/+, that has been associated with severe early-onset obesity and diabetes. By studying this mutation in specially created mouse models, researchers aim to understand how it affects brain function and metabolism. The project focuses on the role of the Otp gene in the hypothalamus, which is crucial for regulating appetite and energy balance. Through these insights, the research seeks to uncover the mechanisms that lead to obesity and glucose intolerance in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with severe early-onset obesity, particularly those who may have a genetic predisposition.
Not a fit: Patients without a genetic link to obesity or those with obesity due to other non-genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating obesity and diabetes.
How similar studies have performed: Previous research has shown success in understanding genetic factors related to obesity, making this approach promising.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Liu, Chen — Ut Southwestern Medical Center
- Study coordinator: Liu, Chen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.