A diverse Alzheimer's genetics resource for Black and Hispanic communities
Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP)
This project collects health information and DNA from Black, African, Caribbean, and Hispanic older adults to learn how genes affect Alzheimer's risk.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11380200 on NIH RePORTER |
What this research studies
The team will recruit, interview, and collect blood or saliva from about 13,000 people of African and Hispanic ancestry, including both people with Alzheimer's or related dementias and people without dementia. They will use community-sensitive approaches to build trust, improve enrollment, and keep people engaged over time. Samples will be genotyped and added to a shared genomics resource so researchers can compare genetic risk across diverse groups. By increasing representation, the project aims to clarify how ancestry-related genetic differences like APOE and ABCA7 affect Alzheimer's risk in understudied populations.
Who could benefit from this research
Good fit: Ideal participants are adults of African, African American, Caribbean, or Hispanic/Latino ancestry who are willing to provide medical history and a blood or saliva sample, whether or not they have dementia.
Not a fit: People who are not of the targeted ancestries or who cannot provide consent or a biospecimen may not directly benefit from this project.
Why it matters
Potential benefit: If successful, it could improve genetic risk prediction and lead to more accurate diagnosis and treatments for Black and Hispanic patients.
How similar studies have performed: Earlier studies have found ancestry-linked differences in Alzheimer's risk genes but have been underpowered, so this larger, focused effort builds on promising but incomplete prior findings.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Pericak-Vance, Margaret a. — University of Miami School of Medicine
- Study coordinator: Pericak-Vance, Margaret a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.