A device to test how chemicals affect ovarian health
An ovary-on-a-chip to identify ovarian toxicity
This study is looking at how certain chemicals and medicines might affect women's ovarian health using a special model that acts like real ovaries, helping us find out which substances could cause problems like hormonal imbalances or infertility, so we can make safer products for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11089498 on NIH RePORTER |
What this research studies
This research investigates the effects of various environmental chemicals and pharmaceuticals on ovarian health using an innovative 'ovary-on-a-chip' model. The device mimics the natural structure and function of human ovaries, allowing researchers to observe how these substances may cause ovarian toxicity, which can lead to issues like hormonal imbalance and infertility. By developing a high-throughput testing method, the research aims to identify harmful chemicals more efficiently, potentially leading to safer consumer products. Patients may benefit from improved understanding and prevention of ovarian-related health issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are reproductive-aged women and prepubertal girls who may be exposed to environmental toxins.
Not a fit: Patients who are not of childbearing age or those with existing severe ovarian dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better safety assessments of chemicals, reducing the risk of infertility and hormonal disorders in women.
How similar studies have performed: Other research has shown promise in using organ-on-a-chip technologies for toxicity testing, indicating a potential for success in this novel approach.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Xiao, Shuo — Rutgers Biomedical and Health Sciences
- Study coordinator: Xiao, Shuo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.