A device to protect insulin-producing cells for diabetes treatment
Official title: Implantable Electrospun Cell Chamber Device with Immune-Evasive Properties for Beta Cell Replacement Therapy
Funded at Biosurfaces · NIH-10756256 · Data updated 2026-11-12
This study is testing a new device that helps protect insulin-producing cells for people with Type 1 diabetes, so they can manage their condition better without needing harsh medications to prevent rejection.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Biosurfaces NIH-funded |
| Lab location | 1 site (Ashland, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $275,766 |
| NIH project number | 1R43DK137616-01 |
| Project ID | NIH-10756256 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Type 1 diabetes who require insulin therapy and are seeking alternative treatment options.
✕Less likely to help
Patients with Type 2 diabetes or those who do not have a need for beta cell replacement therapy may not benefit from this research.
What this research studies
This research focuses on developing an implantable device that encapsulates pancreatic beta cells to protect them from the immune system in patients with Type 1 diabetes (T1D). The device aims to eliminate the need for immunosuppressive drugs, which are currently required to prevent transplant rejection. By creating a more effective encapsulation method, the research seeks to reduce complications such as fibrotic tissue formation that can hinder insulin release. Patients may benefit from a more reliable and long-term solution for managing their diabetes.
Why it matters
Potential benefit: If successful, this research could provide a new treatment option that allows for the replacement of insulin-producing cells without the need for lifelong immunosuppression.
How similar studies have gone: While there have been promising results in encapsulation techniques for cell protection, this specific approach is novel and aims to address persistent challenges in the field.
Where this research is happening
-
Biosurfaces
Ashland, United States Active
Researchers
- Principal investigator: Hayden, Patrick J — Biosurfaces
- Study coordinator: Hayden, Patrick J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.