A detailed map of the human lung across many lung diseases
Cross-Disease Multi-Modality Mapping of the Human Lung
This project creates cell-level maps of adult and pediatric lungs using advanced gene and chromatin measurements to help researchers understand and treat different lung conditions.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11178727 on NIH RePORTER |
What this research studies
This project collects lung tissue and uses single-nucleus Multiome methods (measuring RNA and chromatin accessibility from the same nuclei) to identify which cell types and cell states are present in many lung diseases. The team will compare adult and pediatric samples and perform direct cross-disease analyses to find shared and disease-specific molecular signatures. Data will be integrated across transcriptomic and epigenomic measurements and shared publicly so other researchers can mine it for targets and biomarkers. The goal is to reveal cell-level mechanisms, signaling changes, and extracellular matrix alterations that could guide future therapies.
Who could benefit from this research
Good fit: Ideal participants are adults undergoing clinical procedures or biopsies for lung disease (including patients seen at participating LungMAP centers) who can donate tissue or clinical data for research.
Not a fit: People without lung disease or those seeking immediate treatment benefits should not expect direct, near-term clinical benefit from this mapping-focused project.
Why it matters
Potential benefit: If successful, this work could reveal new disease mechanisms and targets that lead to better diagnostics, treatments, or personalized care for people with lung disease.
How similar studies have performed: Previous LungMAP work produced high-quality pediatric lung single-cell atlases demonstrating feasibility, but direct cross-disease adult mapping at this scale is a new extension.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Sun, Xin — University of California, San Diego
- Study coordinator: Sun, Xin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.