A detailed map of how human cells fix damaged DNA
Mapping systems of DNA repair with high-resolution functional genomics
This project will map DNA-repair processes in human cells to help people with cancer and certain neurological or inherited DNA-repair disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Princeton University NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project ID | NIH-11260376 on NIH RePORTER |
What this research studies
Researchers will use human cells grown in the lab and high-resolution functional genomics to identify which genes and pathways fix different kinds of DNA damage. They will combine systematic gene perturbations with advanced genome-editing tools to see how repair processes work alone and together. The team will specifically study how newer editing methods, like prime editing, interact with the cell's mismatch repair systems. Results are intended to reveal hidden repair relationships and point to factors that influence genome stability and editing outcomes.
Who could benefit from this research
Good fit: People with cancer or inherited DNA-repair syndromes who are willing to donate blood or tissue samples for lab research are the most relevant participants.
Not a fit: Patients seeking immediate clinical treatments are unlikely to receive direct therapeutic benefit from this laboratory-focused project.
Why it matters
Potential benefit: If successful, this work could reveal targets for new cancer therapies and make gene-editing approaches safer and more precise for patients.
How similar studies have performed: Prior genomics studies have identified DNA-repair factors and informed cancer biology, but this high-resolution systems mapping and explicit focus on prime-editing interactions is relatively new.
Where this research is happening
Princeton, UNITED STATES
- Princeton University — Princeton, United States (Active)
Researchers
- Principal investigator: Adamson, Brittany S. — Princeton University
- Study coordinator: Adamson, Brittany S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.