A data hub to understand how lung immunity changes with age
Data Science Core
This project builds a shared data platform to find molecular signs in lung tissue that explain why older people have weaker airway immune responses to viruses.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project ID | NIH-11330391 on NIH RePORTER |
What this research studies
Researchers will create a centralized, searchable data repository that brings together many types of molecular and clinical data from lung samples collected across partner labs. They will build web tools so scientists can view, explore, and generate figures from the data. Using integrated analyses, the team will look for molecular patterns in the airway and immune cells that differ with age and link to poor responses to viral infection. Promising molecules or pathways will be flagged for follow-up laboratory validation and future clinical studies.
Who could benefit from this research
Good fit: Ideal participants include older adults or people who donate lung or airway tissue or who take part in studies of respiratory viral infection at the participating centers.
Not a fit: Because this is a data and discovery effort rather than a treatment trial, people seeking immediate medical benefits are unlikely to benefit directly in the short term.
Why it matters
Potential benefit: If successful, this work could reveal why older adults are more vulnerable to respiratory viruses and point to new targets for prevention or treatment.
How similar studies have performed: Related multi-omic studies have identified age-related immune changes in other tissues, but applying an integrated, shared data platform specifically to lung tissue and viral responses is relatively new.
Where this research is happening
Bar Harbor, United States
- Jackson Laboratory — Bar Harbor, United States (Active)
Researchers
- Principal investigator: Chaussabel, Damien — Jackson Laboratory
- Study coordinator: Chaussabel, Damien
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.