A colon cancer chip that studies how tumors interact with their environment
A microengineered colon cancer-chip designed to investigate tumor-stromal interactions driving cancer progression
This study is creating a special model of colon cancer that closely resembles how tumors grow in the body, using real cancer cells from patients, so researchers can better understand how these tumors behave and respond to treatments, which could lead to better care for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ellison Institute, LLC NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10988276 on NIH RePORTER |
What this research studies
This research develops a microengineered model of colon cancer that mimics the natural environment of tumors. By using advanced organ-on-chip technology, the project aims to create a 3D system that incorporates patient-derived cancer cells and surrounding stromal cells. This model will allow researchers to observe how tumors grow and respond to treatments over time, providing insights that traditional models cannot offer. Patients may benefit from improved understanding of their cancer and more effective treatment options based on these findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with colorectal cancer who are seeking innovative treatment options.
Not a fit: Patients with non-cancerous gastrointestinal conditions or those not diagnosed with colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for colon cancer, improving survival rates and treatment outcomes.
How similar studies have performed: Other research using organ-on-chip technology has shown promise in understanding cancer biology and testing therapies, indicating a potential for success in this approach.
Where this research is happening
Los Angeles, United States
- Ellison Institute, LLC — Los Angeles, United States (Active)
Researchers
- Principal investigator: Mumenthaler, Shannon Michelle — Ellison Institute, LLC
- Study coordinator: Mumenthaler, Shannon Michelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.