A blood test to detect tuberculosis
An Antigen-Detection Blood Test for Pulmonary Tuberculosis
This study is working on making a blood test for tuberculosis (TB) better and easier to use, so it can more accurately tell if someone has active TB or not, helping people at risk in different countries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10654614 on NIH RePORTER |
What this research studies
This research aims to enhance a blood test designed to detect tuberculosis (TB) by improving its accuracy and usability. The team will add specific peptides to the test to increase its sensitivity and specificity, using blood samples from patients with and without TB. They will validate the improved test's performance against standard diagnostic methods and evaluate its effectiveness in distinguishing active TB from other conditions in patients at risk across multiple countries. The ultimate goal is to meet the World Health Organization's criteria for TB screening and diagnosis.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for tuberculosis, including those with symptoms or known exposure to TB.
Not a fit: Patients who have already been diagnosed with active tuberculosis or those without any risk factors for TB may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a more accurate and reliable blood test for diagnosing tuberculosis, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promise in developing blood-based tests for TB, but this approach aims to refine and validate a novel assay.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Catanzaro, Antonino — University of California, San Diego
- Study coordinator: Catanzaro, Antonino
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.