A bile acid metabolite helps improve type 2 diabetes.
"A microbiome-dependent bile acid metabolite improves type 2 diabetes."
This study is looking at how a special substance made by gut bacteria can help people with type 2 diabetes manage their blood sugar better, especially after weight loss surgery, and it hopes to find new, easier ways to treat diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11009904 on NIH RePORTER |
What this research studies
This research investigates how a specific bile acid metabolite, produced in response to gut bacteria, can improve glucose management in individuals with type 2 diabetes. The study focuses on understanding the mechanisms behind the anti-diabetic effects observed after bariatric surgery, particularly sleeve gastrectomy. By exploring the role of the bile acid metabolite cholic acid 7-sulfate (CA7S), the research aims to identify how it activates certain receptors in the intestine to enhance metabolic health. Patients may benefit from insights that could lead to less invasive treatments for diabetes based on these findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with type 2 diabetes, particularly those who may be considering bariatric surgery or have undergone it.
Not a fit: Patients with type 1 diabetes or those who do not have type 2 diabetes are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, less invasive treatments for managing type 2 diabetes.
How similar studies have performed: Previous research has shown promising results in understanding the metabolic benefits of bariatric surgery, suggesting that this approach could yield significant insights.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Sheu, Eric Garland — Brigham and Women's Hospital
- Study coordinator: Sheu, Eric Garland
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.