A Better C. difficile Vaccine
Advancing a second generation C. difficile vaccine
['FUNDING_OTHER'] · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · NIH-11134708
This program aims to create a more effective vaccine to protect people from serious C. difficile infections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR (nih funded) |
| Locations | 1 site (OKLAHOMA CITY, UNITED STATES) |
| Trial ID | NIH-11134708 on ClinicalTrials.gov |
What this research studies
Researchers are working to understand why current C. difficile vaccines don't always provide strong protection. They are studying how the human immune system, specifically memory B cells, responds to the C. difficile bacteria and its toxins. This knowledge will help them develop and test new, improved vaccine candidates. The goal is to create a second-generation vaccine that can better fight off C. difficile infections.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients, but future clinical trials for the vaccine would likely seek individuals at risk for C. difficile infection.
Not a fit: Patients not at risk for C. difficile infection would not directly benefit from this specific vaccine development.
Why it matters
Potential benefit: If successful, this work could lead to a highly effective vaccine that prevents C. difficile infections, reducing severe illness and death.
How similar studies have performed: While first-generation C. difficile vaccines have been explored, this program focuses on understanding their limitations and developing a more advanced, second-generation approach.
Where this research is happening
OKLAHOMA CITY, UNITED STATES
- UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR — OKLAHOMA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LANG, MARK L — UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
- Study coordinator: LANG, MARK L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.