3D MRI to find and describe prostate cancer in men with pelvic metal implants
Novel 3D DWI for Detection and Characterization of Prostate Cancer in Men with Pelvic Metal Implants
This project uses a new 3D MRI method to make prostate cancer easier to find and characterize in men who have hip or other pelvic metal implants.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11001168 on NIH RePORTER |
What this research studies
This work aims to create a 3D diffusion-weighted MRI technique that reduces the image distortion and signal loss caused by metal hip or pelvic implants so the prostate can be seen more clearly. The new scans will be compared with standard multiparametric MRI images to see whether tumors are better localized and characterized. Men would come to Mayo Clinic for the specialized MRI scans and any follow-up biopsies or treatment planning based on the improved images.
Who could benefit from this research
Good fit: Men with suspected or known prostate cancer who have hip or other pelvic metal implants and who can undergo MRI would be the ideal candidates.
Not a fit: Men without pelvic metal implants or those who cannot have MRI scans (for example, due to non-MR-compatible devices) are unlikely to benefit from this specific technique.
Why it matters
Potential benefit: If successful, this could give clearer MRI pictures for men with metal implants, helping doctors target biopsies and plan local treatments more accurately.
How similar studies have performed: Standard mpMRI and diffusion imaging already help detect prostate cancer, but applying a 3D DWI approach specifically to reduce metal-related artifacts is relatively new and not yet widely proven.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Madhuranthakam, Ananth J — Mayo Clinic Rochester
- Study coordinator: Madhuranthakam, Ananth J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.