3D gene folding at the Ets1‑Fli1 region and allergic reactions
3D genome organization of the Ets1-Fli1 locus controls allergic responses
Researchers are looking at whether the 3D folding of genes near Ets1‑Fli1 changes how immune T cells cause allergies in people with asthma, eczema, or other allergic conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11124137 on NIH RePORTER |
What this research studies
If you have an allergy, this project looks at how the genome's three‑dimensional folding in CD4+ T cells controls genes linked to allergic responses, focusing on the Ets1–Fli1 region. Scientists will use computational mapping of 3D chromatin interactions together with laboratory experiments in human T cells and model systems to alter those interactions and observe effects on gene activity and T cell behavior. They will link known genetic variants for asthma and atopic dermatitis to changes in 3D genome architecture and downstream immune signals. The work is mainly lab and computational research and may involve donating blood or tissue samples rather than testing new medicines.
Who could benefit from this research
Good fit: Ideal participants would be people with allergic diseases such as asthma, atopic dermatitis, or other type‑2 immune conditions who can donate blood or clinical samples for research.
Not a fit: People without allergic or type‑2 immune conditions, or those seeking immediate new treatments, are unlikely to get direct benefit because this is basic research.
Why it matters
Potential benefit: If successful, this work could reveal new molecular targets or biomarkers that lead to better diagnostics or future allergy treatments.
How similar studies have performed: Previous studies have linked 3D genome organization to gene control in immune cells, but applying this '3D cliques' approach to the Ets1–Fli1 locus in allergy is a novel direction.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Vahedi, Golnaz — University of Pennsylvania
- Study coordinator: Vahedi, Golnaz
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.