3D downfield brain MR spectroscopy imaging for glioma research
Official title: Downfield MR spectroscopic imaging of the human brain
Funded at University of California at Davis · NIH-11580002 · Data updated 2026-11-12
Researchers will develop advanced 3D downfield MR spectroscopy imaging and open-source analysis tools to study brain tumors in adults, starting with glioma patients and healthy volunteers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $248,999 |
| NIH project number | 4R00EB034768-03 |
| Project ID | NIH-11580002 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with brain tumors (e.g., glioma) and healthy volunteers who can safely undergo high-field MR imaging.
✕Less likely to help
Patients unable to undergo 3T or 7T MR imaging or with contraindications to MR spectroscopy may not benefit.
What this research studies
This project aims to create faster and more sensitive 3D downfield MRSI techniques at 3T and 7T, along with software to quantify and visualize the broad downfield signals in the brain. By establishing normative values and reproducibility, the work seeks to compare downfield MRSI with existing APT-GEST methods in people with brain tumors. The effort includes developing open-source software to make these analyses accessible to clinicians and researchers. The overall goal is to enhance our understanding of brain tumor biology and potentially improve non-invasive monitoring of disease.
Why it matters
Potential benefit: If successful, this work could provide new brain tumor biomarkers from downfield spectra and better imaging options for diagnosis and treatment monitoring.
How similar studies have gone: Previous UF-MRSI work has been productive; DF-MRSI is less explored and this project pushes into novel, open-source methodology.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Ozdemir, Ipek — University of California at Davis
- Study coordinator: Ozdemir, Ipek
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.