3D CT scans to measure bone structure in osteogenesis imperfecta
Project 3: 3D Imaging
Using advanced 3D CT imaging to find better measures of bone strength for people who have osteogenesis imperfecta (brittle bone disease).
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11173436 on NIH RePORTER |
What this research studies
If you take part, doctors will use high-resolution 3D scans of your bones (HR-pQCT for limbs and cone-beam CT for the skull) to look for new imaging signs linked to fracture risk and bone deformities. The project compares these 3D measures with standard 2D bone density tests and clinical findings to find more reliable markers. Scans and follow-up visits are designed to limit radiation exposure while capturing detailed bone structure. The goal is to create validated imaging outcomes that could be used in future clinical trials and care decisions.
Who could benefit from this research
Good fit: People (children and adults) with a clinical or genetic diagnosis of osteogenesis imperfecta who can undergo CT imaging and attend follow-up visits.
Not a fit: People without OI, those who cannot tolerate CT scans, or pregnant individuals would not be expected to benefit from participating.
Why it matters
Potential benefit: If successful, this could provide more reliable imaging markers to track bone health and speed development of better treatments for people with OI.
How similar studies have performed: Past studies using 2D bone density have weak links to fracture risk in OI, while early work with HR-pQCT and CBCT is promising but not yet fully validated for this condition.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Nagamani, Sandesh Chakravarthy Sreenath — Baylor College of Medicine
- Study coordinator: Nagamani, Sandesh Chakravarthy Sreenath
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.