3D Cherenkov imaging to monitor skin radiation during total skin electron therapy
Cherenkov imaging incorporating 3D surface imaging for TSET
Special cameras and 3D surface scans measure the skin radiation dose people get during total skin electron therapy for conditions like mycosis fungoides.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11190782 on NIH RePORTER |
What this research studies
If you take part, cameras will capture faint light (Cherenkov) produced when radiation hits your skin while 3D surface scans map your body shape. The cameras are synchronized with the radiation machine so staff can see real-time video of each treatment. The team will develop corrections for viewing angle, skin curvature, and skin optical differences so the light signal better matches the actual dose delivered to your skin. This pilot clinical trial will use these methods during your total skin electron therapy visits to help document and correct skin dose delivery.
Who could benefit from this research
Good fit: Ideal candidates are patients scheduled to receive total skin electron therapy (for example for mycosis fungoides) who can undergo video and 3D surface imaging during their treatment sessions.
Not a fit: People who are not receiving total skin electron therapy or who cannot be photographed or scanned during treatment would not benefit from this trial.
Why it matters
Potential benefit: If successful, this could help ensure the radiation dose to your skin matches the prescription and allow clinicians to spot and correct setup or movement errors during treatment.
How similar studies have performed: Previous work has shown Cherenkov imaging can map radiation on skin, but combining it with 3D surface corrections for quantitative dose verification is a newer clinical translation.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Zhu, Timothy C. — University of Pennsylvania
- Study coordinator: Zhu, Timothy C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.