3-D genetic imaging inside tissues using DNA microscopy
Volumetric spatial-genetic imaging with DNA microscopy
This project is developing a way to map genetic differences inside three-dimensional tissues to help researchers understand conditions like cancer, brain disorders, and immune problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11176908 on NIH RePORTER |
What this research studies
Researchers are building a method called DNA microscopy that tags DNA and RNA molecules with unique barcodes and uses chemical reactions to record how close those molecules sat to one another inside tissue. The barcodes are converted into a network that lets the team reconstruct detailed three-dimensional maps showing where specific genetic variants and cells are located. The lab aims to apply this volumetric approach to deep tissues such as tumors and brain samples to reveal how mutated cells interact with neighbors during disease processes. If successful, the method would link precise genetic changes to their spatial context within intact tissue.
Who could benefit from this research
Good fit: Ideal participants would be people with tumors, neurological conditions, or immune-related disorders who are willing to donate tissue samples or take part in research biopsies.
Not a fit: People who cannot or will not provide tissue samples, or those seeking immediate clinical treatment rather than research participation, are unlikely to receive direct benefit from this technology development.
Why it matters
Potential benefit: If successful, this could let doctors and scientists see exactly where mutations occur inside tissues, improving understanding, diagnosis, and potentially guiding targeted treatments.
How similar studies have performed: DNA microscopy was first reported in 2019 and represents a novel spatial-genetics approach with early proof-of-concept results but limited clinical application so far.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Weinstein, Joshua — University of Chicago
- Study coordinator: Weinstein, Joshua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.