Drug or treatment

Nemtabrutinib clinical trials

• 10Clinical trials
• 39Countries

Newest trials

All recruiting trials (10)

• Nemtabrutinib in people with severe kidney disease and healthy volunteers

  This study tests how nemtabrutinib behaves in the bodies of people with severe kidney impairment and in healthy volunteers.

  Recruiting Phase 1 Merck Sharp & Dohme LLC · Miami Lakes, Florida · NCT07734610

• Nemtabrutinib Plus Brexucabtagene Autoleucel (Brexu-Cel) in Relapsed or Refractory Mantle Cell Lymphoma

  This phase 2 trial tests whether adding nemtabrutinib to brexu-cel can help people whose mantle cell lymphoma has come back or not responded to prior treatment.

  Recruiting Phase 2 Vanderbilt-Ingram Cancer Center · Nashville, Tennessee · NCT07673367

• Nemtabrutinib plus rituximab for marginal zone lymphoma

  This phase 2 trial tests whether combining nemtabrutinib with rituximab can help people with marginal zone lymphoma.

  Recruiting Phase 2 City of Hope Medical Center · Duarte, California · NCT07583810

• Nemtabrutinib and venetoclax in untreated CLL/SLL

  This phase 2 study tests whether combining nemtabrutinib with venetoclax can help people with untreated chronic lymphocytic leukemia or small lymphocytic lymphoma.

  Recruiting Phase 2 Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT07557056

• Nemtabrutinib plus lisocabtagene maraleucel for relapsed or refractory CLL/SLL

  This will test whether adding the oral drug nemtabrutinib to lisocabtagene maraleucel (CAR T‑cell therapy) helps people with CLL/SLL that has come back or stopped responding to prior treatment.

  Recruiting Phase 2 Fred Hutchinson Cancer Center · Seattle, Washington · NCT07194980

• Nemtabrutinib plus pembrolizumab for Richter transformation (DLBCL subtype)

  This phase II trial tests whether combining nemtabrutinib and pembrolizumab can shrink tumors and help people whose chronic lymphocytic leukemia has transformed into diffuse large B‑cell lymphoma (Richter transformation).

  Recruiting Phase 2 Roswell Park Cancer Institute · Buffalo, New York · NCT06863402

• Combining nemtabrutinib and rituximab to treat mantle cell lymphoma

  This study is testing if combining two treatments, nemtabrutinib and rituximab, can help people with newly diagnosed mantle cell lymphoma feel better and live longer.

  Recruiting Phase 2 City of Hope Medical Center · Duarte, California and 1 other locations · NCT06572618

• Comparing Nemtabrutinib to Ibrutinib or Acalabrutinib for First Line Treatment of Chronic Lymphocytic Leukemia

  This study is testing if a new drug called nemtabrutinib works as well as or better than two existing treatments for people with chronic lymphocytic leukemia who haven’t had treatment before.

  Recruiting at 181 sites Phase 3 Merck Sharp & Dohme LLC · Mobile, Alabama and 205 other locations · NCT06136559

• Comparing two treatments for relapsed chronic lymphocytic leukemia

  This study is testing if a new combination of two drugs, nemtabrutinib and venetoclax, can help people with relapsed chronic lymphocytic leukemia live longer without their cancer getting worse compared to the usual treatment.

  Recruiting at 103 sites Phase 3 Merck Sharp & Dohme LLC · Springdale, Arkansas and 105 other locations · NCT05947851

• Evaluating the effects of nemtabrutinib in patients with blood cancers

  This study is testing a new oral medication called nemtabrutinib to see if it can help people with blood cancers like chronic lymphocytic leukemia and Waldenström's macroglobulinemia feel better and stay safe.

  Recruiting at 94 sites Phase 2 Merck Sharp & Dohme LLC · Springdale, Arkansas and 120 other locations · NCT04728893

Quick answers

How many clinical trials of Nemtabrutinib are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 39 countries. The most sites are in United States (10 trials), Australia (3 trials), Brazil (3 trials), Canada (3 trials), Germany (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 7, Phase 3: 2, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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