Drug or treatment

Loncastuximab clinical trials

• 11Clinical trials
• 3Countries

Newest trials

All recruiting trials (11)

• First-line therapy with Loncastuximab Tesirine and Rituximab for PTLD after transplant

  This trial tests if loncastuximab tesirine plus rituximab can help adults with post-transplant lymphoproliferative disorder after a transplant.

  Recruiting Phase 1/2 University of Utah · Salt Lake City, Utah · NCT07573436

• Combining loncastuximab tesirine and epcoritamab in relapsed/refractory aggressive B‑cell lymphoma

  In this phase 2 study, researchers will test whether the drug combo loncastuximab tesirine plus epcoritamab can help people with relapsed or refractory aggressive B‑cell lymphomas, including DLBCL, HGBL, or FL 3B, who have failed prior therapies or CAR‑T treatment.

  Recruiting at 30 sites Phase 2 Universität Münster · Aachen and 33 other locations · NCT07197307

• Combining Loncastuximab and Roflumilast with R-CHOP for High-Risk Diffuse Large B-cell Lymphoma

  This study is testing a new treatment plan that combines loncastuximab and roflumilast with standard chemotherapy to see if it helps people with high-risk diffuse large B-cell lymphoma do better.

  Recruiting at 2 sites Phase 1 The University of Texas Health Science Center at San Antonio · San Antonio, Texas and 1 other locations · NCT06977711

• Epcoritamab plus loncastuximab tesirine for relapsed or refractory large B-cell lymphoma

  This test gives epcoritamab together with loncastuximab tesirine to adults whose large B-cell lymphoma has come back or not responded, to see if it can shrink or clear the cancer.

  Recruiting Phase 2 University of Miami · Miami, Florida · NCT06919939

• Treatment with Loncastuximab Tesirine for Lymphoma After CAR-T Therapy Failure

  This study is testing if a new treatment called Loncastuximab Tesirine can help people with lymphoma who didn't get better after CAR-T therapy.

  Recruiting at 7 sites Phase 2 Istituto Clinico Humanitas · Alessandria, ALESSANDRIA and 6 other locations · NCT06918912

• Loncastuximab tesirine plus rituximab as bridging therapy before CAR-T for relapsed or refractory large B‑cell lymphoma

  This trial tries loncastuximab tesirine with rituximab as a bridge before commercial CD19 CAR‑T therapy for adults with relapsed or refractory large B‑cell lymphoma to see if it is safe and helps control disease before CAR‑T.

  Recruiting at 2 sites Phase 2 University of Utah · Chapel Hill, North Carolina and 1 other locations · NCT06788964

• Using loncastuximab tesirine and rituximab after targeted radiation for brain lymphomas

  This study is testing if a combination of two medications, loncastuximab tesirine and rituximab, can help adults with certain types of brain lymphomas after they receive targeted radiation treatment.

  Recruiting at 3 sites Phase 1 University of Utah · Philadelphia, Pennsylvania and 2 other locations · NCT06607549

• Treatment for relapsed or refractory diffuse large B-cell lymphoma

  This study is testing a new combination of two treatments for people with relapsed or hard-to-treat diffuse large B-cell lymphoma to see if it helps them respond better and live longer.

  Recruiting Phase 2 City of Hope Medical Center · Duarte, California · NCT05672251

• Using loncastuximab tesirine to treat large B-cell lymphoma after CAR T-cell therapy

  This study is testing if a new treatment called loncastuximab tesirine can help people with large B-cell lymphoma who haven't fully responded to CAR T-cell therapy feel better and stay in remission.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT05464719

• Treatment with Loncastuximab Tesirine for Relapsed Marginal Zone Lymphoma

  This study is testing a new drug called loncastuximab tesirine to see if it helps people with relapsed marginal zone lymphoma feel better after other treatments haven't worked.

  Recruiting at 4 sites Phase 2 University of Miami · Duarte, California and 3 other locations · NCT05296070

• Combining Loncastuximab Tesirine and Rituximab for treating relapsed Follicular Lymphoma

  This study is testing if combining two treatments, Loncastuximab Tesirine and Rituximab, can help people with relapsed Follicular Lymphoma feel better compared to current options.

  Recruiting at 3 sites Phase 2 University of Miami · Fort Myers, Florida and 4 other locations · NCT04998669

Quick answers

How many clinical trials of Loncastuximab are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (9 trials), Italy (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 8, Phase 1: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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