Condition

Opioid Induced Constipation (OIC) clinical trials and research

• 2Clinical trials
• 9Countries

All recruiting trials (2)

• Naldemedine for opioid-induced constipation in people with cancer

  This study will try naldemedine, a gut-acting opioid blocker, to relieve opioid-induced constipation in adults with cancer who still have constipation despite laxatives.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam · NCT07231796

• Evaluating the safety and effects of naldemedine in children using opioids

  This study is testing whether a new medication called naldemedine can help children who are using opioids for pain avoid constipation and stay safe while doing so.

  Recruiting at 4 sites Phase 1/2 Shionogi Inc. · Tirana and 15 other locations · NCT05588323

Quick answers

How many Opioid Induced Constipation (OIC) clinical trials are recruiting right now?

2, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in Netherlands (1 trial), Albania (1 trial), Armenia (1 trial), Belgium (1 trial), Bosnia and Herzegovina (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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