Condition

Neovascular Age-Related Macular Degeneration (nAMD) clinical trials and research

• 5Clinical trials
• 18Countries

Newest Neovascular Age-Related Macular Degeneration (nAMD) clinical trials

All recruiting trials (5)

• Aflibercept 8 mg in real-world neovascular AMD

  This study tests how well aflibercept 8 mg works in real-world patients with neovascular AMD, including those new to treatment and those who have been treated before.

  Recruiting at 6 sites Peking University People's Hospital · Beijing, Beijing Municipality and 26 other locations · NCT07640997

• Long-term safety test of the Axitinib implant for people with neovascular AMD who finished prior OTX-TKI studies

  This study checks long-term safety of the Axitinib intravitreal implant in people with neovascular AMD who completed prior OTX-TKI studies.

  Recruiting at 8 sites Phase 3 Ocular Therapeutix, Inc. · Bakersfield, California and 7 other locations · NCT07516132

• Ixo-vec gene therapy versus aflibercept for wet age-related macular degeneration (AQUARIUS)

  This study tests whether a single injection of Ixo-vec gene therapy can maintain or improve vision as well as regular aflibercept injections in adults aged 50 and older with active neovascular (wet) AMD.

  Recruiting at 79 sites Phase 3 Adverum Biotechnologies, Inc. · Mesa, Arizona and 78 other locations · NCT07482176

• LX102 gene therapy for neovascular (wet) age-related macular degeneration

  This trial will test whether a single subretinal injection of LX102 gene therapy can maintain or improve vision in people aged 50–80 with active neovascular (wet) AMD who previously responded to aflibercept.

  Recruiting at 36 sites Phase 3 Innostellar Biotherapeutics Co.,Ltd · Hefei, Anhui and 35 other locations · NCT07317934

• Single intravitreal injection of 4D-150 for macular neovascularization from age-related macular degeneration

  This trial will try a single eye injection of 4D-150 versus standard aflibercept in adults 50 and older with neovascular (wet) AMD to see if it controls disease activity.

  Recruiting at 11 sites Phase 3 4D Molecular Therapeutics · Scottsdale, Arizona and 125 other locations · NCT07064759

Related topics

Quick answers

How many Neovascular Age-Related Macular Degeneration (nAMD) clinical trials are recruiting right now?

5, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 18 countries. The most sites are in United States (3 trials), China (2 trials), Argentina (1 trial), Australia (1 trial), Bulgaria (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 4. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →