Condition
Metastatic Breast Cancer ( HER2 Negative) clinical trials and research
As of November 12, 2026, Find a Trial lists 3 Metastatic Breast Cancer ( HER2 Negative) clinical trials that are recruiting, at sites in 2 countries (most in China (2), France (1)). By phase: Phase 2 (3). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 3Clinical trials
- 2Countries
Newest Metastatic Breast Cancer ( HER2 Negative) clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| TROP2‑PET and FDG‑PET to predict response to anti‑TROP2 antibody‑drug therapy in advanced HER2‑negative breast cancer | Phase 2 | Shanghai, Shanghai Municipality and 1 other locations | Recruiting | Mar 13, 2026 |
| Using blood ctDNA changes to guide treatment for HER2‑negative metastatic breast cancer | Phase 2 | Shanghai, Shanghai Municipality | Recruiting | Feb 6, 2026 |
| Tucatinib plus trastuzumab for HER3-mutant, HER2-not amplified metastatic breast cancer | Phase 2 | Bordeaux and 8 other locations | Recruiting | Sep 25, 2025 |
All recruiting trials (3)
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TROP2‑PET and FDG‑PET to predict response to anti‑TROP2 antibody‑drug therapy in advanced HER2‑negative breast cancer
See if combining a TROP2 PET scan with an FDG PET scan can predict who with advanced HER2‑negative breast cancer will respond to anti‑TROP2 antibody‑drug treatments.
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Using blood ctDNA changes to guide treatment for HER2‑negative metastatic breast cancer
This study will try using early drops in circulating tumor DNA (ctDNA) after two cycles of antibody‑drug conjugate therapy to decide whether to intensify treatment for people with HER2‑negative metastatic breast cancer.
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Tucatinib plus trastuzumab for HER3-mutant, HER2-not amplified metastatic breast cancer
This trial will test whether combining tucatinib and trastuzumab helps people with metastatic or unresectable breast cancer whose tumors are HER2-negative but carry activating ERBB3 (HER3) mutations.
Related topics
Quick answers
How many Metastatic Breast Cancer ( HER2 Negative) clinical trials are recruiting right now?
3, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 2 countries. The most sites are in China (2 trials), France (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 3. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.