Condition
HR+ HER2- Breast Cancer clinical trials and research
As of November 12, 2026, Find a Trial lists 3 HR+ HER2- Breast Cancer clinical trials that are recruiting, in United States. By phase: Phase 1 (1), Phase 1/2 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 3Clinical trials
- 1Country
Newest HR+ HER2- Breast Cancer clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Combining sapanisertib and serabelisib (PIKTOR) with hormonal therapy for HR+/HER2- advanced breast cancer | Phase 1/2 | Los Angeles, California and 6 other locations | Recruiting | Apr 30, 2026 |
| NKT5097 for adults with advanced or metastatic solid tumors. | Phase 1 | Duarte, California and 18 other locations | Recruiting | Jun 19, 2025 |
| Antibody-drug conjugates for first- and second-line treatment of metastatic HER2‑negative and triple‑negative breast cancer | — | San Francisco, California and 2 other locations | Recruiting | Jan 14, 2025 |
All recruiting trials (3)
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Combining sapanisertib and serabelisib (PIKTOR) with hormonal therapy for HR+/HER2- advanced breast cancer
This trial will test whether combining sapanisertib and serabelisib (PIKTOR) with fulvestrant and other therapies can help people with HR+, HER2- advanced or metastatic breast cancer.
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NKT5097 for adults with advanced or metastatic solid tumors.
This trial tests an oral drug called NKT5097 in adults with advanced or metastatic solid tumors—especially certain breast cancers and tumors with CCNE1 amplification—to see if it is safe and shows anti‑tumor activity.
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Antibody-drug conjugates for first- and second-line treatment of metastatic HER2‑negative and triple‑negative breast cancer
This prospective registry will collect real-world data to see how FDA-approved antibody-drug conjugates work as first- or second-line treatments for adults with metastatic HER2‑negative or triple-negative breast cancer.
Related topics
Quick answers
How many HR+ HER2- Breast Cancer clinical trials are recruiting right now?
3, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
All of them have sites in United States. Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 1: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.