Condition

HFpEF clinical trials and research

• 5Clinical trials
• 4Countries

Newest HFpEF clinical trials

All recruiting trials (5)

• Raising pacemaker heart rate during light exercise to lower left-heart pressures in HFpEF

  This test will try whether temporarily increasing the heart rate by adjusting pacemaker settings during light exercise can lower left-heart filling pressures and improve cardiac output in people with HFpEF who already have a DDD pacemaker.

  Recruiting at 2 sites Universitaire Ziekenhuizen KU Leuven · Hasselt and 1 other locations · NCT07270536

• Adding macitentan to dapagliflozin for people with HFmrEF/HFpEF and combined pre- and post-capillary pulmonary hypertension

  This test will see if adding macitentan to dapagliflozin helps adults with HFmrEF or HFpEF who also have combined pre- and post-capillary pulmonary hypertension.

  Recruiting at 9 sites Phase 4 Gachon University Gil Medical Center · Busan and 14 other locations · NCT07147114

• Identifying predictors of poor prognosis in heart failure with preserved ejection fraction

  This study is trying to find out which factors can help predict bad outcomes for people with heart failure who have preserved ejection fraction.

  Recruiting National Medical Research Center for Cardiology, Ministry of Health of Russian Federation · Moscow · NCT06844032

• Triple-drug therapy (ARNI + SGLT2 inhibitor + MRA) for advanced HFpEF

  This study will test whether giving an ARNI together with an SGLT2 inhibitor and an MRA helps people with advanced HFpEF stay healthier over 52 weeks compared with individualized medical therapy.

  Recruiting Phase 2 National Medical Research Center for Cardiology, Ministry of Health of Russian Federation · Moscow · NCT06655480

• Understanding muscle blood flow in heart failure patients

  This study is testing how exercise training can improve blood flow to muscles and help Veterans with heart failure feel better and exercise more easily.

  Recruiting VA Office of Research and Development · Salt Lake City, Utah · NCT05115890

Related topics

Quick answers

How many HFpEF clinical trials are recruiting right now?

5, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in Russia (2 trials), United States (1 trial), Belgium (1 trial), South Korea (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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